I am little k cellano negative O positive is it hard for me to get blood if needed, please reply as I will need a operation soon I am little k negative o positive Yesterday was the scariest episode my ob detected antibodies in my blood with a K positive . We also don’t know if the baby is definitely negative if antibodies have shown up in the first place…. My hubby is a type 1 diabetic, and (although the public doesn’t seem to know this) blood sugar levels effect spermatogenesis. Your blood type us A and you are Rh. Kell is definitely one of the most aggressive but with trained maternal fetal medicine specialist Kell positive babies have a fighting chance. Your daughter will not be troubled by Kell+ because her body will not attack the fetus either with or without Kell. If they’re present, your doc will closely monitor your pregnancy through blood tests and ultrasounds. There you have it. I’m glad all the other pregnancies were healthy!). I have read a few articles on kell but must have my blonde head on as I can’t get my head round it. What does it mean when a baby is coombs positive? After giving blood twice I recieved a letter letting me know I was A+ kell. It’s not usually tested for, and yet look at the damage it can do! Un groupe sanguin comprend une lettre A, B ou O et un signe + ou –. But they and many other “Kell” antigens are actually ALL part of the “Kell” system. If your hubby has no Kell gene to give your baby, then your body will have no ‘reason’ to attack the fetus, and all should be well. I hope your pregnancy is a very, VERY healthy one with no complications. Nor is she is a drug user. As I am spending a fortune on fertility treatments, and have had every other test in the book done, I would like to find out if the Kell and other antigens/antibodies could have caused the problem. I was thinking maybe my grandson’s mother should get tested just in case. I appreciate your help. Has he been phenotyped. I didn’t really understand it at the time but I was told something about other blood groups (m-/n-?). If you get a non-Kell sperm then (if all else is normal) you will have a healthy pregnancy and a hearty little baby at the end of it without any big medical interventions. This is how immunohematology is performed on the antigen antibody reaction. Because there is a more than 90% chance that one of their parents was Kell negative, and thus had only k genes to bring to the party. I am pregnant and diagnosed as having the anti-Kell antigen. 2. I’m female with the normal blood type O+ This does not, sadly, rule out any other disaster — but from the Kell end of things you should be fine. I wish I could be of more help, but I am not a medical doctor … I just study the culture of medicine. I never had any blood transfusions or other pregnancies in my life, could I get this from my parents or husband? Would you kindly give me you contacts, if possible, I’ll ask you some questions. First, people who are Kell positive are most likely to be Kk instead of KK Why? I have just found out that I had K antibodies in my blood tests in my second pregnancy. I am still confused by this, after I had my first born (daughter) I went to donate blood and was sent a letter that stated there was not a need for my blood type, when I became pregnant with my son I had to go through a amiosenthesis and had a very straining pregnancy. If I am Kell +, & My husband is Kell -, babies + or – is currently unknown . … If you test positive, know what protective steps to take to prevent others from getting sick. However, if the baby before this current pregnancy was Kell positive, now your body has become “allergic” to any Kell positive fetus and will attack your baby. It really was just bad luck that Henry (in theory) had a Kk genotype. For me this was a big shock, I’ve not had any blood transfusions and have had 2 very healthy boys. How can that be? I phoned the midwife to enquire and was told she made a clerical error, no antibodies in my blood. Thank in advance. I went through my last pregnancy (4th child) and had MCA scans, and my baby girl was born healthy and not anemic. The Kell antigens are K, k, Kp a, Kp b, Js a and Js b. They way they check the baby is through ultrasound and Doppler. I would think that happened during your last pregnancy since you had no problem with your pregnancy. He is 100% definitely the father. Menu. but he is also conserned on how his family will twist this around since we dont know much about this anti-body. I had my first two babies via midwife, so I understand the desire for a low-intervention pregnancy and delivery, but if your wife has the anti-Kell antigens then the pregnancy is officially high risk and will need to go the full biomedical intervention route. The babies who had mild jaundice did so most likely because of the “big” antigen groups — A or B. Ok, yes I had it backwards. Gladys Tan. I hope that helps. Okay, let’s call the Kell positive allele “K” and the Kell negative gene “k”. You are not a “freak”. The good news is that a simple test will tell you if your son has it … and the better news is that I think it is highly unlikely. If your next baby has no Kell antigen, then it will be fine. If there is no Kell positive fetus/embryo in your uterus then your body won’t be making the anti-Kell stuff to attack it with, so there shouldn’t be enough to show up. Thus it is critical this is passed off to a dr who specializes in this condition. Also, multiple miscarriages could have been because of a physiological issue in the mother, as well. Their children have the potential genotypes of: We know two things from these squares and the fact Kell positive blood is rare. Hi! But a problem can occur when a Kell-negative mom is somehow exposed to the Kell-positive blood — say, via a blood transfusion. The first pregnancy typically carries to term and produces a healthy infant, even if the infant is Kell positive and the mother is Kell negative. Either way, your babies are safe from issues due to Kell. You can get the boys tested now and then they can warn their wife/partner if and when pregnancy is a possibility. I really REALLY hope that modern medical intervention keeps you and your current baby healthy. Inheritance Patterns. My wife has never had a transfusion nor needle stick. Even if genetically otherwise they SHOULD express K or k, they don’t or barely do. It appears I’m quite an anomaly, but I guess we knew that. That means the partner of the diabetic man is more likely to have miscarriages because the sperm that fertilizes the egg may be “broken”. Hope that helps! What does it mean to be “sex positive?” This is one of those terms that different people define in different ways; however, at the core of most definitions is the idea that we must recognize that human sexuality—in its diverse and myriad forms of expression—is natural and healthy. I am A- with Kell and Kidd antibodies. This post will provide a tad more information as to what it is exactly and how it is transmitted. If you live where you have access to an obstetrician, then there is a lot they can do to make any subsequent kell-effected pregnancies go well. First, congratulations on your healthy family! Okay, I’m trying to remember science in middle school, having a tough time. At that time the MFM usually would do an MCA to check to see if baby appears anemic before the results come back as transfusions can happen as early as 16 wks. Try not to worry. Does that help clear things up at all? After this I was informed that I could not only not donate blood but could not donate plasma, be a organ donor etc. He is 100% the father as well. Think of the protein as the “foundation” the K, k, K3, and many other Kell system antigens “houses sit” on. will that cause his death? Early delivery might also be necessary. Am I at risk for anything because of this antigen?? Your birth with no complications is usual, in that the first pregnancy is almost always “safe” provided there is no blood transfer. I am not a medical doctor, only a medical anthropologist, and I can but speculate that your first born had a K+ blood type and now you have antigens that will attack any K+ tissue, including another Kell+ fetus. Your son will be fine . Your daughter should have no issues (related to blood type) and your son’s partner (if he chooses to have kids as adult and falls in love with a reproductively viable woman!) To clarify what you seem to misunderstand, even blood bankers are guilty of calling “K’ the “Kell” antigen, and “k” the “cellano” antigen. Can you post back here and tell me if all is well or not? He is the father of my two boys, and this third pregnancy where these antibodies have shown up for the first time. It is completely random chance if the baby inherits the Kell gene. Please see Bombay phenotype for a similar situation, these people genetically maybe should be A, or B, but are missing the “foundation” so they don’t express the antigens. Quick question. I have Orthostatic Hypotension and after my 1st baby girl I ruptured a vein causing me to lose blood when I was already anemic and had a lowish blood count. However, not all of the ethnic groups share the same proportions of A positive blood types. Assume all will be well. Moreover, random chance can make a dominate gene go bye-bye even when the dominate gene doesn’t cause the death of many offspring who inherit it. First, I am not a doctor so please don’t hold me up as ‘real’ medical advice! The Kell antigen system (or the Kell-Cellano system) was named after the family of the antibody producer Mrs. Kellacher. For one thing, people who are homozygous (KK) for Kell are rare. The BAD news is that if either of your sons have your blood type then their partners might (and it is a big if considering genetics) have issues IF the partner is a normal K- and IF the second fetus is K+. Because the New Year’s Boy survived for a few weeks and Mary lived to adulthood. But my levels of it were too weak to show up on the titer level. Does this mean my SS2 has a Kell positive blood type and can I get him tested to see? What does kell mean? The #1 explanation for unknown antibodies is a false positive test or clerical error. It could avoid heartbreak in the future. Me, and ALL of my family, sis, mom, aunts are all K pos, because a blood company wanted us to give blood for money to make diagnostics……. Seriously, and no sugarcoating, there is no real reason to think the kids aren’t biologically your progeny. You are a rare case, but obviously that does happen. I hope their next fetus is Kell- or that the Ob/Gyns can do more to help and keep the fetus safe until old enough to be born. It will be a normal pregnancy, like your last one. Or maybe none of them will be. I will not be having any more children, but am concerned that it may be an issue for them when they have children. My last post tried to explain the randomness of the Kell reaction, and I hope it made things clearer. And the most common for Europeans and Africans was the K-k+. If it DOES inherit the Kell bloodtype then your body will attack it again. thanks. If you are antigen typed and are Kell positive this means you cannot make a antibodies to Kell. Well, tune in next post for the exciting adventures of Genealogy Quest! A very simplified version of how a dominate gene (especially one that is harmful under certain conditions) can wind up being in only a small minority of a population. Just remember that my opinion is likely to be inferior to the doctor’s on any point of difference. No worries! This is called hemolytic disease, and it can be lethal. Your spouse must be Kell Positive (no harm- just something attached to his blood- and about 10 percent of the US population). HOWEVER, just being from England (which the name Cary is) means your ancestors had a 9% chance of carrying the gene. However, if all four children are boys then the Kell gene is much less likely to turn up in the grandchildren, because every pregnancy after the FIRST one will only survive if it is Kell negative (kk). Was that the end of the drama? This is my first pregnancy after a year of trying (about 7 weeks now) and I am very worried…Do you have any advice for me please? I sincerely hope all goes well! It sounds like everything will be good, though, so try to stay calm. During the immune response, the woman's body recognises that the RhD positive blood cells are foreign and creates antibodies to destroy them. You are very welcome. If you had the antigens, it would just mean you are Kell positive and it would pose no threat to your pregnancy, but antibodies mean that your blood has been exposed to the Kell proteins. They did blood work for my husband he turn out to be k negative. Kell may become more common now. I worry, a little, for my half-brother and my sister’s son, that they will have trouble if they want 2 kids, or if they have a partner who has had a prior Kell+ transfusion to react to. Kell is the most agressive antibody. Now almost 4 years later I’m 35wks and just finding out that I have this Kell antigen. I’d be worried about the antibodies that you contracted not the antigen Kell. i have some questions about the kell gene and the risks that it might causes of a baby. However, I am currently pregnant and am wondering how it could possibly effect my pregnancies. I wrote you earlier, but my blog didn’t post it. However, it is the third most common blood type which is present in about 1 out of 12 individuals. This reads differently. Never mind about the question, I asked it wrong can a Kk pass only positive onto a child or can they still pass the negative too? Does that mean I got this from my parents? Hi have three boys after the first I had a blood tranfution went on two baby number two at 37 week they found out that i was kell postive but was not informed about it went on to baby three and found out at 17 wèek blood test that I was had kell postive partaner is negative what dose this mean for future pregnants and for the future of the three boys. I have the very rare Kell Kk polymorphism and had several early miscarriages, at least two of my five adult sons who have been tested are carriers and I have a grandson. This is in addition to the ABO blood groups that most people know about. If you are more worried than you are in love, then end the relationship. If two of your sons are Kell positive, I strongly suggest testing everyone. For simplicity’s sake we’ll say brown eyes are “B” and blue eyes are “b”. So when you have a transfusion the antigen is being introduced into the body. Every one of their kids will have brown eyes because of the B, but they will all be carrying the blue b as well. My third child, another daughter was born with no issues whatsoever. My husband has been tested and he is Negative for K (Kell), positive for k (cellano). Many thanks in advance for any advice. I would hate for his future wife to go through the scare I had, or since Dad is Neg & my pregnancy was “normal” is my son kell free? I am anti-k (lowercase) so it is kind of like a cousin to Kell. since then ive had 2 miscarriages til now. Quelles sont les caractéristiques du sang qui déterminent notre rhésus ? Virtually everyone is Kell positive. Thanks! I love my wife and my kids, regardless of their origin. I hope you and your new baby are very healthy! I am have developed anit kell anit bodies I think for a blood transfusion I had way back in 2003 .my question is I have 7 children all from the same dad But a problem can occur when a Kell-negative mom is somehow exposed to the Kell-positive blood — say, via a blood transfusion. I will love to hear this answers to her questions those are the exact questions i have my self thank u. READ MORE. If a mother is found to be Kell positive, the number of antibodies present is determined through the same testing and the mother is given a “score.” This score is referred to as a titer. What I’m not clear on is whether this means I was kell positive from birth and therefore my pregnancy won’t be affected, or kell positive for anti-antigens which I may have picked up from a transfusion during surgery 20 years ago. helloo, IGG antibodies cross the placenta and therefore if the baby has the antigen then a reaction occurs. I’d love to find it. This response is inaccurate. As far as I know (and remember I’m not an MD so if your doctor says otherwise listen to him/her!) There is unlikely to be any insurmountable obstacles preventing your from having children … it may just take longer and be harder. I did indeed *almost* die in the womb, and the Obstetrician said I probably wouldn’t live very long after birth at the rate things were going. Frankly, I am baffled as to how the antibodies got into your system without a blood transfusion or Kk hubby. However, if you have a Kell+ son and his future partner is Kell- then they need to give her a doctor a heads up when/if she gets pregnant. Is Kell only spread by the men? No trouble there either and apparently no prophylaxis or special treatments given to my mother (I asked). The person who proposed to my has the blood type O+ but with kell antigens I didn’t find out until i was preganat with my second child five years later. First, let me congratulate you on your twins! I work in a blood bank, this is NOT true. I contracted the Kell antibody because of a blood transfusion I had after my 1st pregnancy which was a c-sec. Not sure why this came to mind but it dis, perhaps I’m trying to occupy my time while we wait for the blood work. My doctor doesn’t seem too concerned but says it will need monitoring and the baby may be born with some jaundice. If the girl is either Kell positive or negative, it shouldn’t be a problem for her. If the King had not had a “k” gene to give them, they would have died in utero or a few hours after their birth like their poor siblings did. Please understand, I have thought long and hard about this before posting… whatever the answer, the outcome will not end my marriage. What is the Kell factor and how do I get tested for it. the placenta broke inside her thus getting blood from the baby who’s dad tested positive) it’s so complicated and I worry so much since the dr. said her case is the first they have seen in that hospital (they live in Calif. ) . That’s where antigens are located in the red blood cells. The antibodies are usually made after a blood transfusion.. … I was wondering if the woman above ever figured out any answers as to how she contracted the antibody? Since there is only a 50/50 of a first born getting the K gene, maybe only 2 out of the 16 hypothetical grandchildren will be Kell positive. RBcs are packed RBCs they do not contain serum,so with that said RBcs contain antigen. I would recommend retesting Dad because a false negative is the most likely explanation. If all four children are girls, and they each are Kk, then Kell positive blood is very likely to show up in the grandchildren. If the boys are Kell-negative, then they have no worries. It is rare my midwife said to find blood compatible with Kell. I just have a biology degree and study doctors. Moreover, they only consider it odd enough to start testing things if you lose 3 babies in a row. If mom’s brown eyes are Bb, then some of the kids might be blue-eyed, but the brown-eyed kids are all going to be carrying a recessive too. However, a wise doctor would panic and NOT push the issue … just in case. They were pregnant again but lost the baby at 23 weeks due to the problem. I’m assuming in your terminology its KK, and the typical K-k+ from 23andMe is kk? Do you mean you have Kell antibody. Which means ONE (which one is anyone’s guess and it would take bloodtyping to find out) of your former pregnancies had a Kell positive fetus. If the only plausible explanation is infidelity, then my goal would be to work on our marriage to stop the practice. First, I am very sorry for your losses. That being said, a Kell+ woman will not have any problems with pregnancy because of her blood type. Also I think maybe some people are getting g mixed up on this sight. Is it that dangerous ?! Glad it all worked out!!! My baby girl is due in 3 months, even with a c section I can bleed out. But these are “irregular antibodies” because they are not fighting against something harmful. It could be prevented if they would just screen. I hope the information I sent via Facebook chat will help. This means we can use the Punnett square again and see the genotypes of the offspring of a brown-eyed person (BB or Bb) and a blue-eyed person (bb). Also, if a baby is cellano-negative (which it might very well be and indeed probably is) then the body won’t attack the fetus; your antigens won’t “see” anything there to attack. I believe there is a good chance if my son has a Kell blood type that my wife will have K antigens so could you tell me what I should specifically ask the midwife to do regarding this? It can be used in many aspects, referring to: what, how much or how high one gets. Hi there, I just got my first blood test result, it says I have anti K(ell) antibodies. (obsolete) The caul. Thanks in advance for any insight you can provide. i am around 29/30 weeks along in my pregnancy. I’m also going to add a futer amnio should be done by a MFM @ 15-18 wks. Hi Shannon! QED – Henry had a Kk genotype. Once she’s exposed, she develops anti-Kell antibodies, which can attack and destroy Kell-positive red blood cells. (I have found that most doctors and blood centers don’t check for this because it is so rare.) Maybe it is on your post it is pretty late. Even if he does happen to be kell positive (very unlikely) then your baby will still be safe since you don’t have anti-kell antibodies. Hope that helps!!! If it is a first pregnancy, then the mother’s body will not attack the fetus even if it is Kell positive. However, your sibling’s birth is unusual because there should have been enough alloimmunization to effect the pregnancy. My titers have been low… So everything is fine. If you need more support with Kell… Look up the “ISO moms” group on Facebook. After a patient has been identified with an antibody they will receive antigen negative blood for that antibidy the rest of their lives. Should my worries stop or is their any threats to my baby girl?.thank u so much. PLEASE let me know what the results were if you get a son tested for Kell!! Yes. Did the doctors have to take any extra special precautions or anything like that? Or if I get pregnant again will it come back? 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