As exposure variables we investigated total PA, recreational PA, household PA, occupational PA and walking. There were no interactions with other tumor characteristics, BMI or smoking. Among those who did not engage in any sports or cycling before diagnosis, there were more smokers, less women with higher education, less users of menopausal hormone therapy and more patients with large breast tumors. "[77] While calling Stone's performance "phenomenal" stating that she layered "the character with vulnerability, anger, and sadness", Adam Chitwood of Collider felt that the series "should hopefully begin a welcome career resurgence. We assessed the association of pre‐diagnosis PA with recurrence, overall and cause‐specific survival in a prospective cohort study in Germany including 3,393 non‐metastatic breast cancer patients aged 50–74 years. [51][52] As a member of the cast, she was nominated for the Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture, but won the Hollywood Film Festival Award for Best Ensemble Cast. Legaspi, Althea. [13] She was on screen for two minutes and did not appear in the credits. There is convincing evidence that physical activity (PA) is a preventive factor for postmenopausal breast cancer.1 Several biological pathways may take effect on cancer development or progression. Critical response towards Basic Instinct was mixed, but Stone received critical acclaim for her "star-making performance";[16] Peter Travers of Rolling Stone remarked that "[Verhoeven's] cinematic wet dream delivers the goods, especially when Sharon Stone struts on with enough come-on carnality to singe the screen," and observed of the actress' portrayal: "Stone, a former model, is a knockout; she even got a rise out of Ah-nold in Verhoeven's Total Recall. there was no linear dose–response relationship but rather a higher HR for inactivity compared to any activity (Fig. 2020 Mar;44(3):869-875. Hence, inferences about causality in analyses with post‐diagnosis PA on survival may be hampered by reverse causality. At recruitment, in‐person interviews were performed to collect information on demographic, anthropometric, socioeconomic and lifestyle factors including PA, as well as self‐reported information on medications and on comorbidities that had ever been diagnosed by a physician. The prevalence rate of deviations in body constitutions and related factors in follow-up stage breast cancer patients—A nationwide study. Also in the 1980s, Stone appeared Irreconcilable Differences (1984), King Solomon's Mines (1985), Cold Steel (1987), Action Jackson (1988), and Above the Law (1988). [26] Also in 1995, she received a star on the Hollywood Walk of Fame, located at 6925 Hollywood Blvd, and was awarded the Women in Film Crystal Award.[27]. 4 Extended Essays 2013/2014. [61] She played a dermatologist seeking a ménage à trois in the Woody Allen–John Turturro comedy Fading Gigolo, which received a limited theatrical release in April 2014 following its premiere at the 2013 Toronto International Film Festival. In 1985, she appeared in an episode of T. J. Hooker ("Hollywood Starr") opposite William Shatner. In contrast, the best fitting models for overall mortality, breast cancer‐specific mortality and mortality due to other causes included PA in the form PA−0.5, i.e. To investigate the dose–response relationship, recreational PA was included in the models in different polynomial forms following the algorithm for multiple fractional polynomials (Fig. The endpoints of interest were overall mortality, breast cancer‐specific mortality, other deaths and local or distant recurrence. Following Basic Instinct, photographer George Hurrell took a series of photographs of Stone, Sherilyn Fenn, Julian Sands, Raquel Welch, Eric Roberts, and Sean Penn. She also obtained the role of a literary agent and former lover of a mystery writer in the thriller Where Sleeping Dogs Lie (1991). In another Verhoeven film, the erotic thriller Basic Instinct (1992),[5] she took on the role that made her a star, playing Catherine Tramell, a brilliant bisexual and alleged serial killer. Sensitivity analyses were performed for all three mortality endpoints by excluding patients with in situ or with late‐stage breast cancer (Stage IIIb and IIIc). Stone was criticized over her comments in an exchange on the red carpet with Hong Kong's Cable Entertainment News during the 2008 Cannes Film Festival on May 25, 2008. Other adjustment sets considering the following covariates were also investigated, but did not alter the HRs for the PA variables by more than 10%: type of surgery (mastectomy, breast conserving), chemotherapy (yes/no), hormone therapy (yes/no), HER2‐neu status, postmenopausal at diagnosis (yes/no), marital status (married, single, separated, divorced, widowed), alcohol use at diagnosis (0, >0 to <19, ≥19 g/day), previous myocardial infarction (yes/no), peripheral arterial obstructive disease (yes/no), osteoporosis (yes/no), rheumatoid arthritis (yes/no), venous thrombosis (yes/no), previous pulmonary embolism (yes/no), chronic lung disease (yes/no), chronic liver (yes/no), gastric or renal diseases (yes/no), psychological disorders (yes/no), migraine (yes/no), thyroid disorders (yes/no), previous myoms (yes/no) or ovarian cysts (yes/no). Possible effect modification by tumor characteristics (in situ/invasive; low + moderate/high grade; ER+PR+/ER−PR−/other), pre‐diagnosis BMI (<25/≥25), smoking status (ever/never) or pre‐existing cardiovascular diseases (yes/no) was assessed by including an interaction term in the regression models. [112] The divorce became final in 2004,[113] with a judge ruling that Roan should remain primarily with Bronstein, with Stone receiving visitation rights. Determinants of newly diagnosed comorbidities among breast cancer survivors. [85] In 1999, she was rated among the "25 sexiest stars of the century" by Playboy. However, these considerations include solely patients who completed the long‐term follow‐up interview, hence excluding patients who have died or were too ill to respond. [citation needed] She was signed by Ford Modeling Agency in New York City. for Tanzania in 5 minutes", Primetime Emmy Award for Outstanding Guest Actress in a Drama Series, Allan Quatermain and the Lost City of Gold, MTV Movie Award for Most Desirable Female, Golden Globe Award for Best Actress in a Motion Picture – Drama, Golden Globe Award for Best Supporting Actress, Best Actress in a Motion Picture – Comedy or Musical, Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture, Satellite Award for Best Supporting Actress in a Series, Miniseries, or Television Film, 2008 Shanghai International Film Festival, List of awards and nominations received by Sharon Stone, Rolling Thunder Revue: A Bob Dylan Story by Martin Scorsese, "Joseph William STONE II's Obituary on Los Angeles Times", "An unlikely friendship: Caroline Morahan and Sharon Stone bond over Ireland", "Sharon Stone Recreates Her "Basic Instinct" Leg Cross", "Reason Sharon Stone hails turning 60 as her "greatest achievement, "Basic Instinct': The Suspect Is Attractive, and May Be Fatal", "Basic Instinct (1992)website=Box Office Mojo", "Weekend Box Office : Ticket Sales Up Despite Mother Nature", "The Specialist (1994)website=Box Office Mojo", "THE QUICK AND THE DEAD – Festival de Cannes", "Movie Review : Forget the Cerebral. The health and protection of the rights of women also has an impact on children and therefore society. For breast cancer‐specific mortality, deaths from breast cancer (coded as ICD‐10 C50) were events of interest and deaths from other causes were censored at date of occurrence. For breast cancer recurrence, a linear dose‐response showed up as the best fitting term (ptrend = 0.067). [123], In a career spanning over four decades, Stone has had over one hundred acting credits in film and on television. However, the associations between inactivity and overall or cause‐specific mortality were observed only among patients who had a low or normal BMI in the years before diagnosis. She has been married to James Caan since October 7, 1995. the dichotomized inactivity variable) by pre‐diagnosis BMI (<25, ≥25 kg/m2) was observed (pinteraction = 0.063), showing a significant association with inactivity (HR = 1.63 (1.23, 2.17)) only among women with BMI < 25 (Table 3). Stone was considered academically gifted as a child and entered the second grade when she was 5 years old. [49] The film premiered at the 2006 Sundance Film Festival and was an arthouse success. "[59] She took on the leading female role in the French action sequel Largo Winch II as a United Nations investigator named Diane Francken. The best‐fitting transformation based on the −2 log likelihood of the respective model was selected. Use the link below to share a full-text version of this article with your friends and colleagues. One potential explanation is that the cardio‐toxic effect of many cancer therapies may influence the relationship between PA and mortality. 1933), an accountant, and Joseph William Stone II (1930–2009),[3] a tool and die manufacturer and factory worker. Association between pre-diagnosis BMI, physical activity, pathologic complete response, and chemotherapy completion in women treated with neoadjuvant chemotherapy for breast cancer. 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